By Business Wirevia The Motley Fool
Filed under: Investing
POZEN Announces Results from a Burden of Cardiovascular Disease Study: a Managed Care Perspective
Presentation at AMCP Demonstrates Cost Reduction When PPI Used in Combination With Aspirin for Both Commercial and Medicare Populations
CHAPEL HILL, N.C.–(BUSINESS WIRE)– POZEN Inc. (Nasdaq: POZN), a pharmaceutical company committed to transforming medicine that transforms lives, announced the results of a POZEN sponsored study at the Academy of Managed Care Pharmacy’s 25th Annual Meeting and Expo on April 4, 2013. Ryan S. Clark, Pharm.D., MBA, Health Outcomes and Managed Markets Fellow, Global Health Economics & Outcomes Research at Xcenda, presented the abstract, The Burden of Secondary Cardiovascular Disease in Commercial and Medicare Patients: A Managed Care Perspective. The secondary prevention of cardiovascular events includes the daily use of aspirin. Chronic aspirin therapy is associated with significant gastrointestinal (GI) toxicity including dyspepsia, gastric ulcers and GI bleeding, all of which contribute to the disease and cost burden of secondary prevention. The GI toxicity of aspirin can be mitigated by the use of proton pump inhibitors (PPIs). The Xcenda analysis demonstrated that the prevention of cardiovascular events with aspirin, plus a PPI, compared to aspirin alone is associated with a net per-patient per-year cost decrease of $103 and $145 and a potential overall cost decrease of $1.8 million and $11.0 million for a typical one million-member Commercial and Medicare Plan, respectively.
“The overall cost of secondary cardiovascular events in patients with a history of coronary heart disease, transient ischemic attack, or ischemic stroke represents a significant financial burden on managed care,” said Rashad Carlton, Pharm.D., MSPH, Assistant Director, Global Health Economics & Outcomes Research at Xcenda. “Despite American College of Cardiology and American Heart Association guideline recommendations to start aspirin therapy and continue indefinitely in all patients unless contraindicated, aspirin remains underutilized.”
About the Study
The primary objective of the study was to characterize the financial burden of secondary cardiovascular disease and its long-term complications in patients at risk for a secondary cardiovascular event.
An economic model designed to yield the annual secondary cardiovascular disease cost burden was constructed using literature-based population, medication discontinuation/non-adherence, and cardiovascular event incidence data. Care records of secondary cardiovascular disease patients were reviewed based on treatment either with aspirin, aspirin + PPI, or no aspirin. Secondary events were calculated based on annual recurrence rates adjusted for treatment discontinuation/non-adherence. The treatment cohort cost per member and …read more
Source: FULL ARTICLE at DailyFinance


