Tag Archives: VL

Emergent BioSolutions Presents Efficacy Data on ES210; a Bispecific ADAPTIR Molecule for Treating Au

By Business Wirevia The Motley Fool

Filed under:

Emergent BioSolutions Presents Efficacy Data on ES210; a Bispecific ADAPTIR Molecule for Treating Autoimmune Diseases

ROCKVILLE, Md.–(BUSINESS WIRE)– Emergent BioSolutions Inc. (NYS: EBS) announced today that it has presented data on ES210, one of its bispecific ADAPTIRTM (Modular Protein Technology) molecules, that is targeting autoimmune disease at Keystone Symposia’s Advances in the Knowledge and Treatment of Autoimmunity in Whistler, British Columbia, Canada.

The ES210 molecule was engineered using Emergent’s ADAPTIR technology platform and contains binding sites specific for CD86 coupled to a monomeric form of IL-10 known to confer immunosuppressive activity.

The poster, entitled A Bispecific ADAPTIR™ Molecule That Targets CD86 and Delivers IL-10 Inhibits Antigen Presenting Cells and Has Potential as a Therapeutic Treatment of Autoimmune Disease,”presentedpre-clinical data showing that ES210 displays high levels of in vitro and in vivo potency in blocking T-cell proliferation in human mixed lymphocyte reactions and in a humanized graft-versus-host disease model. Dendritic cells play a central role in the generation and regulation of immunity; therefore, targeting dendritic cell function represents a therapeutic opportunity to suppress immunopathological processes in autoimmune disease.

“Emergent is investigating an ADAPTIR molecule that targets and blocks the co-stimulatory receptor CD86, while delivering the immunosuppressive cytokine IL-10 to CD86-expressing antigen presenting cells,” said Jane Gross, Ph.D., vice president of applied research at Emergent BioSolutions. “We are pleased to present the study results, which show the ADAPTIR molecule as having potential applications in the treatment of transplant rejection as well as autoimmune and inflammatory diseases such as Crohn’s disease, ulcerative colitis, and rheumatoid arthritis.”

About the ADAPTIR™ Platform

ADAPTIR bispecific proteins are modular, single chain polypeptides that comprise two separate binding domains (VL and VH), a hinge segment, and an effector domain (huFc). They have a differentiated structure from monoclonal antibodies and can generate a unique signaling response. In addition, ADAPTIR proteins may mediate complement dependent cytotoxicity and Fc dependent cytotoxicity, similar to monoclonal antibodies.

ADAPTIR is the new trademark for Emergent BioSolutions Inc.’s modular protein technologies that were previously identified using the SCORPIONTM (multispecific protein therapeutic) and SMIPTM (monospecific protein therapeutic) trademarks. ADAPTIR and any and all Emergent BioSolutions Inc. brand, product, service and feature names, logos and slogans are trademarks or registered trademarks of Emergent BioSolutions Inc. or its subsidiaries in the United States or other countries. All rights reserved.

About Emergent

From: http://www.dailyfinance.com/2013/04/11/emergent-biosolutions-presents-efficacy-data-on-es/

The Continental: Best and Worst of the 2013 Detroit Auto Show

By Jens Meiners

The Continental

Each week, our German correspondent slices and dices the latest rumblings, news, and quick-hit driving impressions from the other side of the pond. His byline may say Jens Meiners, but we simply call him . . . the Continental.

Volkswagen CrossBlue concept

Detroit is the most important American auto show by far. As a German, it is endlessly fascinating to check out the American and Asian cars at the show, many of which are not sold in my home country. Those that are sold there often come with vastly different powertrains and design features. This year’s Detroit show was rife with awesome styling concepts and even a few surprises. Here is my personal take on some of the cars and technologies I came across on the show floor.

Best Concept: Volkswagen CrossBlue. Yes, I know the styling doesn’t knock anyone’s socks off, but it is well executed to the last beautiful detail—and it packs a lot of them, such as the angular, U-shaped daytime running lights. The concept’s interior is futuristic and it boasts quite forward-looking technology, such as a Schaeffler-supplied electric rear axle. Volkswagen’s MQB modular architecture is designed to incorporate this unit with few changes, and we will see it on production VW Group cars soon.

Lincoln MKC concept

Worst Concept: Lincoln MKC Concept. Ford’s design department under J Mays seems to be falling back into an old pattern. Remember the Ford Five Hundred, a blatant ripoff of Peter Schreyer’s Volkswagen B5 Passat? I can just imagine Mays ordering Lincoln chief designer Max Wolff to take an Audi Q5 and morph it to the Ford Escape’s package. From the side window opening to the wraparound tailgate, the MKC is embarrassingly lacking in originality. Several Ford designers have worked in Audi and VW design, but shouldn’t they be allowed to move on?

2014 Chevrolet Corvette Stingray

Best Production Car: Chevrolet Corvette. America’s sports-car icon is taking a big leap forward. Its styling is aggressive enough to appeal not only to the aging Corvette collector crowd, but also to a new, younger set of buyers. The front grille may be somewhat unexceptional, but the headlight design is refreshing; the side view is novel and even slightly Italian; and the angry rear end is simply fantastic. Thank you, Chevrolet, for not allowing this icon to be clinic’d to death. The C7 Vette goes the extra 25 percent the C6 wasn’t allowed to go, and as a result it will be considered a great Corvette.

2014 Jeep Compass Latitude

Worst Production Car: Jeep Compass. This car is hardly worth mentioning, but it represents the mindset that prevails when “car guys” take the back seat in a car’s development. Cynically exploiting the Jeep brand, this pseudo-SUV has become a barely acceptable vehicle almost seven years after its launch. It resembled a diminutive Grand Cherokee for a few years, but now its big brother is getting a facelift, leaving the Compass behind yet again. It is a sad fact that the Compass was conceived when Dieter Zetsche and Wolfgang Bernhard were calling the shots at Chrysler, as they are now at Mercedes-Benz.

2014 Cadillac ELR

Best Exterior: Cadillac ELR. The series production ELR does not deviate far from the look laid down by the stunning Converj concept from a few years back, and I like everything about it. Slim, futuristic, and true to Cadillac’s unique design language, it brings enormous appeal to the notion of owning an electric vehicle. Let’s hope that the ELR’s on-road performance, with its boosted Volt powertrain, is anywhere near what the styling promises, so that it won’t need the VL Industries treatment (see below).

2014 Mercedes-Benz CLA

Worst Exterior: Mercedes-Benz CLA. Almost eight years ago, I wrote a requiem for German design in a commentary for Automotive News. Back then, I argued that restraint and simplicity have gone out the door in favor of voluptuous lines and nonfunctional styling—and that was before Gorden Wagener became head of design at Mercedes-Benz. From my somewhat purist perspective, things certainly haven’t improved. That said, taste in styling is personal, and anyone who likes the looks of the CLA, a self-proclaimed “style rebel,” will be positively thrilled by its dynamic capabilities. And I concede the small Benz’s look is functional: It has the one of the lowest drag coefficients of all series production vehicles on the market.

By the way, as we are speaking of simplicity and restraint: Why did every Audi—the high-performance 2014 RS7 included—on the stand in Detroit have chrome wheels?

Best Interior: Toyota Avalon. I opened the door of this Japanese Buick only to check if they still fitted a front bench seat; the last Avalon I bothered to peek into (some years ago) was so equipped. To my utter surprise, I was met with one of the most beautifully styled instrument panels I’ve seen in this class. It has a layered surface, soft and hand-stitched padding, and a brushed-metal center zone fitted with precisely machined knobs just like on a 1970s high-end stereo. (Which most Avalon customers likely vividly remember.)

2013 Cadillac XTS Platinum interior

Worst Interior: Any Cadillac with CUE. Actually, GM’s luxury brand has some of the best interiors in the marketplace—clever, functional, aesthetically pleasing. But for me, the CUE infotainment system ruins the experience. Not only is it slow to respond and sometimes counterintuitive, I deplore the pitiful graphics. Come on, an ancient telephone receiver to symbolize the phone function? An antique globe to represent navigation? There even are 1970s-style symbolized bodies for the climate controls and OnStar, plus a child’s drawing of a cloud for the weather. It gets worse as you move on, delving into a world of overlapping rectangles and wide, empty spaces on the screen. This inexplicable mix of shapes and styles is unworthy of Cadillac. Ford’s SYNC, with all of its shortcomings, is an application that is far more pleasant to look at.

VL Automotive Destino

Biggest Surprise: VL Industries Destino. This Fisker Karma, stripped of its battery pack and electric powertrain, delivers one of the nastiest blows to E-mobility to date. The factory Karma is built around the notion of “sustainable mobility,” and VL’s dumping a naturally aspirated or supercharged 6.2-liter Corvette V-8 into its engine bay is about as sensitive as showing up at the local co-op in a camo-colored Hummer H1. The incredulous eyes of my European colleagues upon stumbling over the Destino were priceless. Can this be allowed? Yes.

Acura NSX Concept

Biggest Yawn: Acura NSX. It seems time to move beyond the NSX sports car even before this never-ending launch is finally over. I really look forward to driving the actual car, but the new model’s surprise factor and mystique will have been squandered by the time it hits the road.

Ford Atlas concept

Best Truck: Ford Atlas. Okay, this will be another long-haul launch, but for now, this thinly veiled next-generation F-150 is bold, well executed, and pleasantly technical in its styling language. I like the look, and I like the fact that it appeared in Detroit by surprise.

2014 Chevrolet Silverado 1500 LTZ

Worst Truck: GM’s new-for-2014 full-size pickup trucks for GMC and Chevrolet. GM’s design leadership in trucks was last asserted with the 1988 C/K—and lost to the Dodge Ram in 1994. Since then, it has been a downhill slide for the General, with the 2014 Chevy and GMC trucks figuring as the current low point. I suppose the trucks aspire to boldness, but, in fact, the pair represents one of the most timid redesigns I have seen. Apart from a few gimmicky details, calling these rigs “evolutionary” would be an overstatement.

Source: FULL ARTICLE at Car & Driver

Bob Lutz: Destino is the Fisker Karma people will actually want

By Sebastian Blanco

Filed under: ,

vl automotive destino

Bob Lutz has had grandiose performance luxury car dreams before – Cunningham C7, anyone? – but the VL Automotive Destino that was just unveiled at the Detroit Auto Show was certainly a surprise, even to long-time Lutz-watchers. As a reminder, the Destino is a Fisker Karma with a 638-horsepower supercharged LS9 V8 transplanted from a Chevrolet Corvette ZR1. Plug? Gone. High-tech lithium-ion battery? Sold back to Fisker.

“I just heard so many people say, I love the Fisker Karma but I’m not going to buy it because I don’t want that electric drivetrain.”

For now, the Destino project remains small. Bob Lutz tells AutoblogGreen that VL Automotive has so far purchased eight Karmas, and two have been turned into finished engineering prototypes. Fisker says a total of 20 have been ordered. Still, Lutz believes this is a car with an audience. “I just heard so many people say, I love the Fisker Karma but I’m not going to buy it because I don’t want that electric drivetrain with the four-cylinder engine,” he said. “So, when you think about it, for a car in that category, here’s this ultra-luxurious, super-low, super-sporty, beautifully designed four-door sedan. Probably ten percent of the possible customers want that in an electric form with a four-cylinder.”

To satisfy the other 90 percent Lutz envisions, VL Automotive buys the Karmas and then removes the battery pack (carefully setting it aside) at VL Automotive’s headquarters in Auburn Hills, Michigan – not far from Lutz’s old job at Chrysler. “We were able to run the driveshaft right down the battery tunnel and we had to make a modification where the battery tunnel ends and the rear firewall starts, because the Corvette transaxle intruded somewhat, so we had to make a little aluminum doghouse that’s welded to the vertical rear panel,” Lutz told us. “They had a gas tank, but there’s all this room left over.” In the future, the conversions will be even easier, since VL will buy glider chassis direct from Valmet, in Finland, Lutz said.

From Fisker’s point of view, buying the Karmas whole is actually a good thing, Lutz believes. “[Fisker] has had incredible hard luck,” he said, “And with the battery supplier not producing batteries, they’re actually glad if we buy new ones and ship the batteries and the electrical back to them for a credit – that permits them to build more cars.”

That’s a nice, symbiotic relationship, but Roger Ormisher, Fisker’s senior director of global corporate communications & PR, confirmed to AutoblogGreen that this project is not a joint partnership or strategic alliance. He added:

Fisker believes that it [Destino] speaks to the appeal of the Karma and its stunning, award-winning design that coachbuilders are wanting to take our cars and modify and customize them. We join many famous brands in automotive history that have been the subject of customization and modification.

When the Destino becomes available, the price is expected to be around $180,000.

Bob Lutz: Destino is the Fisker Karma people will actually want originally appeared on Autoblog Green on Fri, 18 Jan 2013 11:28:00 EST. Please see our terms for use of feeds.

Permalink | Email this | Comments

Source: FULL ARTICLE at Autoblog

Destiny’s Child: VL Automotive Debuts the Karma-Based Destino [2013 Detroit Auto Show]

By Andrew Wendler

VL Automotive Destino

Retirement means different things to different people; for auto-industry superhero Bob Lutz it means business as usual, keeping in the mix with not one, but two automotive startups. But as where VIA motors is taking GM trucks and vans and electrifying them for fleet customers, VL Automotive is taking Fisker Karma hybrids and transforming them to run on fossil-fueled GM horsepower.

Never one to waste time or mince words, Lutz has joined forces with Gilbert Villarreal, president of Auburn Hills–based automotive supplier the Concorde Group, to form VL Automotive. Together, they aim to “build an American-made sports sedan with advanced aesthetics that can beat the best from Italy and Germany while maintaining a high level of reliability.” (Last we checked the Fisker Karma body was assembled in Finland, so unless they’re secretly planning to assemble the bodies here, they may need to amend the “American-made” part.) If all goes according to the dynamic duo’s plan, restyled Fisker Karmas with a GM-sourced V-8 under the hood will be rolling off the line of their assembly plant by late 2013.

VL Automotive Destino supercharged 6.2-liter V-8 engine

Dubbed the Destino, VL Automotive has made a few cosmetic changes to the Karma, the most obvious being a completely new hood, new front and rear fasciae, a new decklid spoiler, and the replacement of the solar panel roof with a traditional piece. Not only do the changes improve the car’s visual appeal, but, according to company spokesman Tom Sundberg, also were required to meet the exclusive contract VL Automotive hammered out with Fisker.

The conversion uses the entire Corvette powertrain: Available with a choice in V-8 powerplats—the 6.2-liter LT1 or the supercharged 6.2-liter LS9—coupled to a rear transaxle via a torque-tube setup, the Destino utilizes some of the newfound, battery-vacated space to house an entirely new rear subframe assembly (required to support the transaxle). The LT1-powered car is rated at 450 horsepower and the LS9-motivated Destino at 638 horsepower; transmission options are limited to a four-speed automatic or a six-speed manual. “When we get it dialed in, we’d like to be able to say it’s a 200-mph supercar,” said Sundberg.

Don Runkle, current EcoMotors CEO and former chief engineer for Chevrolet, who was on hand for VL’s press conference in Detroit offered C/D a few succinct words regarding the recent efforts of Lutz and Co.: “When I was at GM, we always asked ourselves, ‘Should we build a four-door Corvette?’ To me, that’s what it looks like they’ve done. And it’s got the right-size battery for a high-performance car, which is zero.”

VL Automotive Destino

The two cars on display in Detroit are the first examples assembled from the first eight Karmas purchased by VL (the remaining vehicles are being used for development and marketing purposes). VL figures the first 20 or so will be built from decontented Karmas, but is in the process of negotiating terms for a supply of gliders—Karmas with no powertrain installed—direct from Fisker. This must be music to the ears of Fisker, who halted production last fall because of the bankruptcy of its battery supplier.

Pricing, as you might expect, is yet to be announced although we’re hearing that it will cost somewhere around the $180,000 range. One of the vehicles VL placed on its stand already has been sold to the owner of an unnamed company that is supplying VL Automotive with components for the Destino.

Destino essentially means “destiny” in Spanish, and as far as VL is concerned, it’s inevitable that a car as stunning as the Karma would eventually have a powertrain that can back up its looks. Sounds like fate to us.

VL Automotive Destino

2013 Detroit Auto Show full coverage

Source: FULL ARTICLE at Car & Driver