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Amarantus Announces Preclinical Development Timeline for MANF Therapeutic

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By Business Wirevia The Motley Fool

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Amarantus Announces Preclinical Development Timeline for MANF Therapeutic

SUNNYVALE, Calif.–(BUSINESS WIRE)– Amarantus BioScience Holdings, Inc. (OTCQB: AMBS), a biotechnology company discovering and developing treatments and diagnostics for diseases associated with neurodegeneration and apoptosis, today provided a timeline of key activities and milestones related to the preclinical development of MANF (Mesencephalic-Astrocyte-derived Neurotrophic Factor). The Company is currently focused on developing MANF across three broad categories: Parkinson’s disease and Traumatic Brain Injury; large systemic applications such as Ischemic Heart Disease and Diabetes; and orphan indications.

“We plan to move forward on a number of fronts this year with MANF, leading potentially to one or more Investigational New Drug (IND) filings in 2014,” said Gerald E. Commissiong, President and Chief Executive Officer of Amarantus. “The pace and scope of activities outlined today reflect the unique properties of MANF, the positive results reported earlier this year in neuroprotective and neurorestorative animal models of Parkinson’s disease and supportive data from the published literature.”

The upcoming activities related to Amarantus’ Parkinson’s disease program include:

  • Create mammalian GMP production processes for MANF; the Company has sourced the expertise for these activities, and has started development of the supporting analytical and bioanalytical assays;
  • Form a partnership agreement in the third quarter of 2013 with a firm specializing in Convection-enhanced delivery (CED) of drugs to the brain;
  • Initiate non-human primate pharmacology studies in Parkinson’s disease models in the second half of 2013 in order to establish an appropriate dosing regimen for human clinical studies;
  • Potentially evaluate MANF gene therapy based upon upcoming developments in the field of neurotrophic factors for Parkinson’s disease, and the Company’s current patent position whereby the Company owns exclusive rights to MANF gene therapy applications in all vector systems.

Additional planned activities are expected to include:

  • Conduct pharmacokinetic and pharmacodynamic (PK/PD) studies, with data available in the third quarter of 2013, to evaluate the biological properties of MANF when administered systemically, with data to be released as it becomes available;
  • Conduct pharmacology studies in traumatic brain injury, ischemic heart disease, diabetes and certain other animal models in the third quarter of 2013, with data to be released as it becomes available;
  • Evaluate MANF in a

    From: http://www.dailyfinance.com/2013/04/11/amarantus-announces-preclinical-development-timeli/

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Amarantus BioScience to Hold Business Update Conference Call on April 16

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By Business Wirevia The Motley Fool

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Amarantus BioScience to Hold Business Update Conference Call on April 16

SUNNYVALE, Calif.–(BUSINESS WIRE)– Amarantus BioScience, Inc. (OTCQB: AMBS), a biotechnology company discovering and developing treatments and diagnostics for diseases associated with neurodegeneration and apoptosis, today announced it will hold a conference call on Tuesday, April 16, 2013 at 4:30 p.m. Eastern (1:30 p.m. Pacific) to provide an update on its business and conduct a question and answer session with investors.

Individuals interested in listening to the conference call may do so by dialing 877-407-8033, or for international callers 201-689-8033. The call is also being webcast, and can be accessed from the Company’s Web site (www.amarantus.com) and at www.InvestorCalendar.com.

A telephone replay will be available through May 1, 2013 by dialing 877-660-6853, or for international callers 201-612-7415, and entering the Conference ID #: 411612. The webcast replay will be available for 90 days following the completion of the call.

During the call Amarantus Chief Executive Officer Gerald Commissiong will recap key accomplishments of 2012 and the first quarter of 2013, provide clarity on the Company’s recently updated business model and discuss business and product development initiatives planned for the remainder of 2013.

About Amarantus BioScience

Amarantus BioScience, Inc. is a development-stage biotechnology company founded in January 2008. The Company is focused on developing unique products and proprietary technologies for the potential treatment and/or diagnosis of Parkinson’s disease, Traumatic Brain Injury, Ischemic Heart Disease and other human diseases. The Company owns the intellectual property rights to Mesencephalic-Astrocyte-derived Neurotrophic Factor (“MANF“) and is developing MANF-based products as treatments for neurological disorders where there is a significant unmet medical need. The Company also is a Founding Member of the Coalition for Concussion Treatment (#C4CT), a movement initiated in collaboration with Brewer Sports International seeking to raise awareness of new treatments in development for concussions and related nervous-system disorders. For further information please visit www.Amarantus.com.

Forward Looking Statements

This press release contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. Such statements include, but are not limited to, statements about the possible progress of the MANF technology in testing for Parkinson’s disease, as well as statements about expectations, plans and prospects of the development of Amarantus’ diagnostic product candidates. These forward-looking statements are subject to a number of risks, …read more

Source: FULL ARTICLE at DailyFinance

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Amarantus BioScience Modifies Business Structure to Support Product Development Strategy

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By Business Wirevia The Motley Fool

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Amarantus BioScience Modifies Business Structure to Support Product Development Strategy

Corporation will change name to Amarantus Bioscience Holdings, Inc.

SUNNYVALE, Calif.–(BUSINESS WIRE)– Amarantus BioScience, Inc. (OTCQB: AMBS), a biotechnology company discovering and developing treatments and diagnostics for diseases associated with neurodegeneration and apoptosis, today announced it will adopt a holding company structure with separate business units in order to more effectively develop its various assets. Reflecting the change in structure, the corporation will change its name to Amarantus Bioscience Holdings, Inc.

Initially, the Company will form two business units: Amarantus Therapeutics, centered on its patented therapeutic protein Mesencephalic Astrocyte Neurotrophic Factor (MANF), and Amarantus Diagnostics, focused on developing the LymPro Blood Test for Alzheimer’s disease and the NuroPro Blood Test for Parkinson’s disease. Currently, MANF is in preclinical testing as a potentially disease-modifying treatment for Parkinson’s disease, and the two diagnostic tests are being prepared for Phase 2 studies. The Company will also evaluate the acquisition/in-licensure of clinical-stage drug candidate to complement MANF within the Amarantus Therapeutics subsidiary, and may evaluate additional strategic significantly undervalued opportunities over time using its deep industry knowledge and connections.

“While our near-term development objectives remain the same, the new structure will allow us to allocate capital more efficiently, and form management teams specific to each business or product line,” said Gerald E. Commissiong, President and Chief Executive Officer of Amarantus BioScience. “We will also be able to create new business units to leverage other assets we already own, such as our PhenoGuard Protein Discovery platform, or that we may acquire. Additionally, we have decided not to spinoff Amarantus Diagnostics at this time, and will re-evaluate the potential spinoff of various business units as the situation with each entity unfolds.”

In conjunction with the new business structure and name change, the Company’s common stock will be given a new CUSIP code for the clearing and settlement of trades following confirmation with the various authorities. The Company will disclose the exact timing of this change in a future regulatory filing once final timing information is available.

About Amarantus BioScience

Amarantus BioScience, Inc. is a development-stage biotechnology company founded in January 2008. The Company has a focus on developing certain biologics surrounding the intellectual property and proprietary technologies it owns to treat and/or diagnose Parkinson’s disease, Traumatic …read more

Source: FULL ARTICLE at DailyFinance

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Amarantus BioScience Appoints Adam J. Simon, Ph.D., to Board of Advisors

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Amarantus BioScience Appoints Adam J. Simon, Ph.D., to Board of Advisors

SUNNYVALE, Calif.–(BUSINESS WIRE)– Amarantus BioScience, Inc. (OTCQB: AMBS), a biotechnology company discovering and developing treatments and diagnostics for diseases associated with neurodegeneration and apoptosis, has appointed Adam J. Simon, Ph.D., to its Board of Advisors. Dr. Simon is a world expert in the field of Alzheimer’s disease biomarkers and has significant expertise in the development of in-vitro diagnostics.

“Dr. Simon will play an important role in the development of our LymPro diagnostic blood test for Alzheimer’s disease,” said Gerald E. Commissiong, President and Chief Executive Officer of Amarantus BioScience. “He is a recognized leader in the discovery of Alzheimer’s biomarkers, and has advised both major pharmaceutical companies and early stage research companies on their clinical programs and regulatory submissions. Dr. Simon is also an entrepreneur in his own right, and understands the specific challenges and opportunities we face here at Amarantus.”

Dr. Simon is the founder and president of AJ Simon Enterprises, LLC, a consulting firm serving pharmaceutical and biotechnology clients, including Bristol Myers Squibb. He is also the founder and chief executive officer of Cerora, Inc., a healthcare information technology company focused on developing medical devices and services to assess brain health, including Traumatic Brain Injury. Earlier in his career he spent more than 13 years at Merck Research Laboratories, where he served as a Senior Research Fellow in Integrative Systems Neuroscience and Biomarkers and in Alzheimer’s disease research. He has also been a visiting scientist at Princeton University.

Dr. Simon received Bachelor’s degrees in Physics and Mathematics from the University of Rochester. He received a Doctorate in Physics from the University of Chicago. He holds four patents related to medical research, and has published more than 60 articles in scientific and medical journals.

About Amarantus BioScience

Amarantus BioScience, Inc. is a development-stage biotechnology company founded in January 2008. The Company has a focus on developing certain biologics surrounding the intellectual property and proprietary technologies it owns to treat and/or diagnose Parkinson’s disease, Traumatic Brain Injury, Ischemic Heart Disease and other human diseases. The Company owns the intellectual property rights to a therapeutic protein known as Mesencephalic-Astrocyte-derived Neurotrophic Factor (“MANF“) and is developing MANF-based products as treatments for brain disorders. The Company also is a Founding Member of the Coalition for Concussion Treatment (#C4CT), a movement initiated in collaboration with Brewer Sports International seeking to raise awareness of new treatments in development for concussions and nervous-system …read more
Source: FULL ARTICLE at DailyFinance

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Amarantus BioScience Reports Positive MANF Data in Neuroprotection Animal Models of Parkinson's Dise

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By Business Wirevia The Motley Fool

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Amarantus BioScience Reports Positive MANF Data in Neuroprotection Animal Models of Parkinson’s Disease

Company’s proprietary therapeutic appears to protect key dopamine-producing brain function

SUNNYVALE, Calif.–(BUSINESS WIRE)– Amarantus BioScience, Inc. (OTCQB: AMBS), a biotechnology company discovering and developing treatments and diagnostics for diseases associated with neurodegeneration and apoptosis, today reported positive preclinical data for its lead therapeutic MANF in neuroprotection 6-hydroxydopamine (6-OHDA) rat models of Parkinson’s disease. The data show that MANF protects the integrity of dopamine producing neurites in the striatum.

“Our scientists are excited by this data, which not only demonstrates the efficacy of MANF, but its superiority to GDNF, as well,” said Gerald E. Commissiong, President and Chief Executive Officer of Amarantus BioScience. “Based on this study, we believe MANF plays a role in maintaining brain connectivity, specifically the dopaminergic system of the basal ganglia network, which reinforces the potential of MANF as a disease-modifying treatment for Parkinson’s.”

In the neuroprotection study, MANF was delivered into the substantia nigra shortly before injection of the toxin 6-OHDA into the striatum. Four weeks later the animals were sacrificed and the density of dopaminergic neuron projections in the striatum was determined. The protection of neuron health, as measured by the density of neurite terminals, was evident in all three areas of the striatum examined. The effects of a single MANF treatment were evident after four weeks, indicating the effects of MANF protection are sustained. Furthermore, the highest level of neurite density was found at the highest dosage of MANF. Importantly, the neurite density measured under treatment with MANF was statistically significantly better than shown for both vehicle control and a standard dosage of Glial cell-Derived Neurotrophic Factor (GDNF). GDNF is currently in clinical trials for Parkinson’s disease and considered the current benchmark in the field. The data summarized here suggests that MANF may have advantages over GDNF for the clinical treatment of Parkinson’s disease.

“The data on MANF continues to return more favorable results than other molecules currently in clinical development as disease-modifying treatments for Parkinson’s disease,” said Dr. Joseph Rubinfeld, Amgen co-founder and current member of the Company’s Board of Advisors. “We intend to conduct select additional experiments to understand why this appears to be the case while we continue the IND-enabling studies that have already been initiated. We believe these additional data points will further distinguish MANF from competitors in the field, and will deliver significant value in the near-term.”

…read more
Source: FULL ARTICLE at DailyFinance

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Amarantus BioScience Appoints Mark Benedyk, Ph.D., to Board of Directors

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Amarantus BioScience Appoints Mark Benedyk, Ph.D., to Board of Directors

SUNNYVALE, Calif.–(BUSINESS WIRE)– Amarantus BioScience, Inc. (OTCQB: AMBS), a biotechnology company discovering and developing treatments and diagnostics for diseases associated with neurodegeneration and apoptosis centered around its patented therapeutic protein Mesencephalic Astrocyte Neurotrophic Factor (MANF), has appointed Mark Benedyk, Ph.D., to its Board of Directors. Dr. Benedyk has over 18 years of experience as a senior business development executive and consultant to life science companies, and has served as a Corporate Advisor to Amarantus since 2011. With the addition of Dr. Benedyk, the Amarantus board has four members, two of whom are considered independent directors, including Dr. Benedyk.

“I am excited to join the Amarantus board at such an important stage of the Company’s scientific and business development growth,” said Dr. Benedyk. “I look forward to helping the Company as it advances MANF towards the clinic for Parkinson’s disease, and executes a commercial strategy for its promising clinical diagnostic tests for Parkinson’s and Alzheimer’s disease.”

Gerald E. Commissiong, President and Chief Executive Officer of Amarantus BioScience, stated “Mark Benedyk has played a significant role in the growth and success of several leading healthcare companies. With his knowledge and understanding of clinical development and regulatory affairs, as well as the financial and operating requirements of a development-stage company, Mark will be an important resource for all aspects of managing our progress and creating value for shareholders.”

Dr. Benedyk is currently a Managing Partner at Rila Partners LLC, a business and corporate development consultancy. In this role he serves on the Strategic Advisory Board of KemPharm, Inc., is a Director at the Center for Drug Research and Development Ventures, Inc., and is a member of the Translational Medicine Advisory Board of the CNS Regenerative Medicine Foundation. Previously he was head of The Pfizer Incubator (TPI) where his duties included membership on the TPI Board of Directors, board positions with TPI portfolio companies, oversight of the TPI operations team, and reviewing investment opportunities in multiple technologies.

Dr. Benedyk has held executive business development roles at Ascenta Therapeutics, Optimer Pharmaceuticals, Aurora Biosciences (acquired by Vertex Pharmaceuticals), and Elan Pharmaceuticals, where he led partnering efforts for several key clinical-stage products for the treatment of Alzheimer’s Disease, migraine and other neurological indications. He received his Ph.D. in Developmental and Molecular Genetics from The Rockefeller University, and Bachelor of Science degree in Microbiology and Botany from the University of Michigan.

About Amarantus BioScience

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Source: FULL ARTICLE at DailyFinance

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Amarantus BioScience, Brewer Sports International and TCMG Announce #C4CT Concussion Awareness Confe

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Amarantus BioScience, Brewer Sports International and TCMG Announce #C4CT Concussion Awareness Conference

Conference will feature sports and neurology experts discussing concussion issues with an emphasis on addressing and identifying research, development and treatment opportunities

SUNNYVALE, Calif.–(BUSINESS WIRE)– Amarantus BioScience, Inc. (OTCQB: AMBS), a biotechnology company discovering and developing treatments and diagnostics for diseases associated with the neurodegeneration and apoptosis centered around its patented therapeutic protein MANF, Brewer Sports International (BSI) and Toi Cook Management Group (TCMG) today announced joint hosting of the Coalition for Concussion Treatment (#C4CT) Concussion Awareness Conference (#C4CT Conference) in Minneapolis on June 19, 2013 at the Minneapolis Club.

The #C4CT Conference is the opening event of the three-day Brewer Sports Symposium, which also includes the 3rd Annual Sports Law for Rookies and Veterans CLE and Sports and Social Impact seminar. The #C4CT Conference will focus on important scientific, medical, translational and prevention-related topics of Traumatic Brain Injuries (TBI) and their long-term impacts on athletes and soldiers. Conference panels will include industry experts, international business leaders and current and former professional athletes. The Brewer Sports Symposium is part of the 8th Annual Blue Carpet Celebrity Weekend hosted by The Jack Brewer Foundation.

“Traumatic Brain Injuries and their effects on amateur and professional football players are emerging as a rallying point to better understand the brain and how we can improve currently available methods to treat it,” said Gerald E. Commissiong, President and CEO of AMBS. “We are proud to be among the first to unite the groups directly affected by these issues, in particular current and former professional athletes, with the scientists, physicians and entrepreneurs who will ultimately lead the way in developing solutions to these devastating problems. We believe that by educating athletes on the basics of concussions, and what additional resources are needed to achieve certain critical steps on the road to better treating the brain, we will give all parties a chance to partake in this emerging field of medical research.”

The #C4CT Conference will include presentations and panel discussions on the following key topics:

  1. Scientific understanding of Traumatic Brain Injury and the long-term scientific implications
  2. Current medical practice and what doctors believe are the key areas of unmet medical need
  3. Translational models available and additional tools needed to accelerate research

    4. …read more
    Source: FULL ARTICLE at DailyFinance