Tag Archives: BMJ

Merck's $5.7 Billion Diabetes Franchise Vulnerable

By YCharts, Contributor

A retrospective analysis published by the BMJ supports previously published findings that diabetic patients taking drugs which target the incretin system to control their blood sugars are at greater risk for developing pancreatic problems, such as acute pancreatitis and pancreatic cancer. Could certain big pharma manufacturers be vulnerable to a price collapse, should European and U.S. regulators – whom are now actively reviewing data on adverse events – move to restrict usage or outright remove these therapies from the market due to questionable safety? …read more

Source: FULL ARTICLE at Forbes Latest

Is It Worth Getting a Flu Shot? The Answer May Surprise You…

By Sean Williams, The Motley Fool


Source: Centers for
Disease Control and Prevention.

I believe some of this plays into common misconceptions that the flu shot will make you sicker, as well as the fact that researchers are doing nothing more than giving you their best guess as to which strain will be dominant this year. Without certainties, more people than the CDC would like are opting not to get vaccinated.

Conversely, this represents a major growth opportunity for flu vaccine makers. These include:

  • FluMist by AstraZeneca : This is the only nasal spray approved by the FDA, and, according to AstraZeneca, it produced 12 million doses for this year’s flu season. Despite having no needles involved, sales of FluMist haven’t taken off as many analysts had expected.
  • Fluzone by Sanofi : As of January, Sanofi’s Fluzone had sold better than expected, with the company producing 60 million doses and selling out of certain aspects of its immunization therapy. Fluzone comes with a particularly shorter and less intimidating needle, which induces less apprehension over “getting a shot.”
  • Fluvirin by Novartis : Novartis’ Fluvirin shipped roughly 36 million doses through mid-January and works in similar fashion to Fluzone. One of the big difference is its approval, which ranges from age 4 and up, versus Fluzone, which can be used in infants as young as six months.
  • Fluarix, Flulaval, and Relenza by GlaxoSmithKline : Flulaval is a vaccine that Glaxo has been supplying regularly for nearly a decade. Fluarix is an “

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Every year, it appears that flu season starts earlier and earlier, and somehow, every year, the virus mutates into its “most virulent form ever.” Sometimes it’s a wonder we even survive with the way that news stations discuss the near-plague that sweeps across the country beginning every fall and extending into winter. Yet, we persevere based on a combination of factors, including good genetics, healthy eating habits, making smart life choices, and, supposedly, in some cases, by getting a flu shot.

Keep that needle away, Doc
The jury has definitely been shown both sides of the coin when it comes to the effectiveness of annual flu vaccines. On one hand, physicians will admit that the flu shot is not a cure-all potion that will prevent the flu. Researchers, each year, must take their best guesses based on the data available on what strains of the flu will be circulating and hope that they’ve given flu vaccine manufacturers the proper guide to protect our growing, and aging, population. These guesses are often fairly accurate, but they don’t produce perfect results.

There’s also quite a bit of skepticism regarding the effectiveness of existing flu medications like Tamiflu, which was developed by Gilead Sciences and licensed to Roche . In November, a researcher linked to the British Medical Journal called for European Union nations to sue Roche for not divulging all of its Tamiflu records in 2009 when requested. Roche countered by noting that it released all pertinent legal information, but refused to release confidential patient-level data to the BMJ researchers. The World Health Organization added Tamiflu to its “essential medicines” list, which resulted in many countries stockpiling the medication. However, the vaccine is simultaneously being investigated by the European Medicines Agency (Europe’s version of the Food and Drug Administration) for not reporting the side effects — including deaths — for 19 separate drugs, including Tamiflu, used on approximately 80,000 people in the U.S. 

The numbers don’t lie
On the other hand, the Centers for Disease Control and Prevention have made it quite statistically clear that there exists demonstrable evidence that flu shots serve a benefit to the greater population. Whether it be in reducing the severity or longevity of the illness, or building the body’s immune system up to support against the virus, the CDC is clear in recommending that people over the age of six months get vaccinated annually.

The CDC posted its mid-season update for 2012-2013 on this year’s vaccine effectiveness (known as VE) on Feb. 21. To my astonishment, the figures were actually quite encouraging. The CDC‘s VE estimate for protection all age groups was 56%. This year’s vaccine was 47% effective against flu A — the H3N2 virus, which is the most common virus this season – and 67% effective against flu B. These results might underwhelm some of you, but the end result is that patients who developed flu A had their chance of hospitalization …read more
Source: FULL ARTICLE at DailyFinance

Go On, Have Another Cup: Caffeine May Reduce Auto Accidents

If you like coffee as much as we do, this Friday is about to get a whole lot better. Not only does java make a great eye-opener, but according to a report in BMJ (formerly the British Medical Journal), it could also keep you safer on the road. That claim comes from researchers in Australia, who interviewed 1,047 long-haul truck drivers — 530 of… …read more
Source: FULL ARTICLE at The Car Connection

Stronger Statin Doses Tied To Kidney Injury

A new study finds that high potency statins are tied to higher risk of being hospitalized for acute kidney injury compared with less potent statins and that the risk persists for two years. Lead researcher Colin Dormuth, of the University of British Columbia, in Vancouver, Canada, and colleagues, write about their findings in a BMJ paper that was published online on 19 March… …read more
Source: FULL ARTICLE at Medical News Today

High Potency Statins Linked To Increased Risk For Acute Kidney Injury

By Larry Husten, Contributor Although the beneficial effects of high-potency statins have been well-characterized in clinical trials, these same trials have lacked the power to illuminate rare but potentially important adverse events. A suggestion of one such area of concern, acute kidney injury, was first raised in the SATURN trial. Now, a new study published in BMJ provides further information about this area. …read more
Source: FULL ARTICLE at Forbes Latest

A brief history of toilet hygiene

By hnn

The last time I visited Boston’s Museum of Fine Arts was in 2004 to see a Rembrandt exhibition. But I might have wandered away from the works of the Dutch master in search of an ancient Greek artifact, had I known at the time that the object in question, a wine vessel, was in the museum’s collection. According to the 2012 Christmas issue of the BMJ (preacronymically known as the British Medical Journal), the 2,500-year-old cup, created by one of the anonymous artisans who helped to shape Western culture, is adorned with the image of a man wiping his butt.

That revelation appears in an article entitled “Toilet Hygiene in the Classical Era,” by French anthropologist and forensic medicine researcher Philippe Charlier and his colleagues. Their report examines tidying techniques used way back—and the resultant medical issues. Such a study is in keeping with the BMJ‘s tradition of offbeat subject matter for its late December issue—as noted in this space five years ago: “Had the Puritans never left Britain for New England, they might later have fled the British Medical Journal to found the New England Journal of Medicine.”

Source:
Scientific American

Source URL:
http://www.salon.com/2013/03/13/a_history_of_toilet_hygiene_partner/

Date:
3-13-13

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Source: FULL ARTICLE at History News Network – George Mason University

Popular Antidepressants May Put Patients At Risk For Serious Arrhythmias

By Larry Husten, Contributor In August 2011 the FDA issued a safety communication recommending that the extremely popular antidepressant citalopram (Celexa) not be used at doses greater than 40 mg/day because of a potential increased risk for serious cardiac arrhythmias associated with prolongation of the QT interval. Now a study published in BMJ lends support to this warning and suggests that other antidepressants may also prolong the QT interval.
Source: FULL ARTICLE at Forbes Latest

Acute Kidney Injury Associated With Dual Antihypertensive Therapy And NSAIDs

By Larry Husten, Contributor Adding a non-steroidal anti-inflammatory drug (NSAID) to dual antihypertensive therapy (a diuretic plus either an ACE inhibitor or an angiotensin receptor blocker) is associated with an increase in risk for kidney injury, according to a large new retrospective study published in BMJ. Analyzing data from nearly half a million people taking antihypertensive drugs, […]
Source: FULL ARTICLE at Forbes Latest

Scent Detecting Dogs Can Sniff Out Hospital Infections

Dogs are now able to sniff out clostridium difficile with significant accuracy in samples of feces as well as the air around patients in the hospital, suggests a new study published in BMJ. Clostridium difficile is an infective component that causes many hospital acquired infections. A detection dog can recognize clostridium difficile in stool, thus identifying sick patients…
Source: Medical News Today